ea0070oc4.2 | Pituitary and Neuroendocrinology | ECE2020
Agosti Emanuela
, De Feudis Marilisa
, Angelino Elia
, Belli Roberta
, Alves Teixeira Maraiza
, Zaggia Ivan
, Raiteri Tommaso
, Scircoli Andrea
, Graziani Andrea
, Prodam Flavia
, Sanpaolesi Maurilio
, Costelli Paola
, Ferraro Elisabetta
, Reano Simone
, Filigheddu Nicoletta
Sarcopenia, the decline in muscle mass and functionality during aging, might arise from age-associated endocrine dysfunction. Indeed, muscle wasting follows the general decline in trophic hormones and the establishment of a chronic mild inflammatory status characteristic of aging. Ghrelin is a gastric hormone peptide circulating in both acylated (AG) and unacylated (UnAG) forms that have anti-atrophic activity on skeletal muscle. AG is the endogenous ligand of the growth hormo...